Amoxicillin Drug Uses

Amoxil is an antibiotic in the class of drugs called penicillin. It fights bacteria in the body. Amoxil is used to treat many different types of infections, such as tonsillitis, pneumonia, ear infections, bronchitis, urinary tract infections, gonorrhea, and infections of the skin. Amoxil may also be used for other purposes.

How Taken

Amoxil comes as a capsule, chewable tablet, liquid, and pediatric drop to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amoxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid and pediatric drops well before each use to mix the medication evenly. Use the bottle dropper to measure the dose of pediatric drops. The pediatric drops and liquid may be placed on a child's tongue or added to formula, milk, fruit juice, water, ginger ale, or other cold liquid and taken immediately. The tablets should be crushed or chewed thoroughly before they are swallowed. The capsules should be swallowed whole and taken with a full glass of water. Continue to take Amoxil even if you feel well. Do not stop taking Amoxil without talking to your doctor.

Amoxicillin Warnings/Precautions

If you have ever had an allergic reaction to another penicillin or to a cephalosporin, do not take Amoxil without first talking to your doctor. Before taking Amoxil, tell your doctor if you have kidney disease, or stomach or intestinal disease. Amoxil is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Amoxil is generally considered to be safe for use during pregnancy. Do not, however, take Amoxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Amoxil passes into breast milk. Although serious problems have not been reported, rarely, Amoxil may cause a yeast infection, diarrhea, or an allergic reaction in a nursing infant, although no serious harm is expected. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Amoxicillin Missed Dose

Take the missed dose as soon as you remember, and take the rest of the day's doses at evenly spaced intervals. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and take the rest of the doses for the day as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Amoxicillin Possible Side Effects

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. If you experience any of the following serious side effects, stop taking Amoxil and seek emergency medical attention or contact your doctor immediately: an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); seizures; or unusual bleeding or bruising. Other, less serious side effects may be more likely to occur. Continue to take Amoxil and talk to your doctor if you experience mild nausea, vomiting, diarrhea, or abdominal pain, white patches on the tongue (thrush/ yeast infection); itching or discharge of the vagina (vaginal yeast infection); black, "hairy" tongue or sore mouth or tongue. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Amoxicillin Storage

Keep out of the reach of children. Store away from heat and direct light. Do not store the capsule or tablet form of Amoxil in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Store the oral liquid form of Amoxil in the refrigerator because heat will cause this medicine to break down. However, keep the medicine from freezing. Follow the directions on the label. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Amoxicillin Overdose

Symptoms of an Amoxil overdose may include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, or agitation. Seek emergency medical attention if an overdose is suspected.

More Information

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. Take all of the Amoxil that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Amoxil may decrease the effectiveness of birth control pills. If you are taking birth control pills, use a second method of birth control while taking Amoxil to ensure protection from unintended pregnancy.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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In September 2002, a patient with a chronic foot ulcer checked into a Pennsylvania hospital. Doctors later discovered that the ulcer contained Staphylococcus aureus bacteria, one of the most common causes of hospital infections.
The bacteria were resistant to vancomycin, the antibiotic of last-resort in fighting infections. It was only the second case of vancomycin-resistant staph reported in the United States. The Pennsylvania physicians also had evidence the bacteria had acquired these resistance genes from another species of bacteria often found in hospitals, Enterococcus faecalis.
Antibiotic resistance is a frightening reality. Now, scientists are a step closer to understanding how antibiotic resistance spreads in the microbial world because the genomes of two gut bacteria have been sequenced.
The microbes, which usually live harmlessly in our intestines, are Bacteriodes thetaiotaomicron and Enterococcus faecalis.
Their genomes contain an incredible amount of mobile elements—DNA that can move around on chromosomes, among organisms and even between species. Mobile DNA can carry genes for virulence and drug resistance, as well as benign genes.
“These mobile elements give bacteria the ability to quickly pass on traits,” says Ian T. Paulsen, who led the enterococcus genome-sequencing project at the Institute for Genomic Research (TIGR) in Rockville, Maryland.
Until sequencing the entire genome, scientists did not realize that a quarter of enterococcus’ genome is made-up of mobile DNA. In fact, its genome contains one of the highest percentages of mobile elements ever seen in bacteria. Within these regions are genes for vancomycin resistance and for virulence.
It had long been established that enterococcus has mobile elements, says Gary M. Dunny of the University of Minnesota in Minneapolis, who studies the bacterium.
“But until now, we have never had a picture of the entire genome of one strain and the total number of mobile elements, which is remarkably high,” he says. TIGR sequenced a strain from a patient with the first case of vancomycin-resistant E. faecalis in the United States.
Bacteriodes is also rich in mobile elements, although these do not harbor antibiotic resistance genes. Jeffrey I. Gordon of Washington University School of Medicine in St. Louis, Missouri, led the bacteriodes project.
“Bacteriodes is not carrying these genes now, but they can pick them up,” says Abigail A. Salyers of the University of Illinois in Urbana-Champaign. Salyers has also served as president of the American Society of Microbiology.
“There is much greater potential for transferring resistance genes than we thought,” she adds.
The genomes of bacteriodes and enterococcus reinforce something scientists have been concerned about for years: the remarkable fluidity of the bacterial gene pool. This fluidity allows bacteria to exchange DNA to enhance their ability to cause disease or their resistance to antibiotics.
“It’s really becoming a problem now because we’re running out of antibiotics,” says Michael S. Gilmore of the University of Oklahoma in Oklahoma City. Gilmore studies enterococcus, and wrote a commentary accompanying the two papers in Science.
Bacteriodes (top) and Enterococcus (bottom)
(top) Courtesy J. Gordon (bottom) © Gloria Delisle and Lewis Tamalty, ASM MicrobeLibrary
Bacteriodes, enterococcus and staph are just a few examples of bugs that are becoming increasingly difficult to treat. The widespread use of antibiotics puts selective pressure on only the hardiest bacteria to survive—which often carry virulence or drug resistance genes.
“We’re facing something we’ve never faced before—the loss of a cure,” says Salyers. New antibiotics are expensive and difficult to develop and “pharmaceutical companies are shutting down antibiotic programs,” she adds.
Hospitals are breeding grounds for some of these dangerous microbes. When you enter a hospital, your intestines carry a normal consortium of microbes. But taking antibiotics can kill susceptible bacteria and leave room for resistant enterococci to take up residence.
These bacteria are lurking on medical instruments and surfaces—just waiting to be ingested and find a niche in your body. The drug-resistant, opportunist enterococci are then poised to infect other parts of the body like surgery wounds, the urinary tract and bloodstream.
The gut environment also contributes to the spread of dangerous genes because enterococcus and bacteriodes live along with over 500 species of bacteria. In fact, there are more bacteria in our intestine than cells in our body.
These gut bacteria are in contact with one another and with other bacteria that pass through the intestine, where they can swap virulence and resistance genes.
“Your colon is a like a singles bar,” says Salyers. “Bacteria are passing DNA around like there’s no tomorrow.”

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